Several lymphoid cells, including T cells, natural killer (NK) cells, and regulatory T cells (Tregs), express the T cell Ig and ITIM domain (TIGIT) on their surface. Numerous investigations have revealed that TIGIT identifies the most dysfunctional subgroup of Tregs and CD8+ T cells, exhibiting a highly suppressive behavior in many scenarios. Furthermore, TIGIT blocking has therapeutic advantages in various animal tumor types.
April 19, 2025