The protein that this gene encodes is a member of the thioredoxin (Trx) system and of the pyridine nucleotide-disulfide oxidoreductase family. Mammals contain three different isozymes of thioredoxin reductase (TrxR). Thioredoxins and other substrates are reduced by selenocysteine-containing flavoenzymes called TrxRs, which are essential for maintaining redox homeostasis. This gene […]